Quotes

The development of treatments for disorders affecting the brain and spinal cord—collectively the Central Nervous System (CNS)—is perhaps the most challenging and high-risk area within all of medicine

. Despite decades of intense research, a profound unmet need persists for conditions ranging from neurodegenerative diseases like Alzheimer's and Parkinson's to psychiatric disorders, chronic pain, and spinal cord injuries. The obstacles are inherent to the biology of the CNS and encompass issues of access, target identification, and the complexity of the diseases themselves.

The Formidable Biological Obstacle: The Blood-Brain Barrier (BBB)

The primary physical barrier to therapeutic success is the Blood-Brain Barrier (BBB), a highly selective interface composed of specialized endothelial cells that tightly regulate the passage of substances from the bloodstream into the CNS tissue. This biological security system, while essential for protecting the brain from toxins and pathogens, simultaneously prevents the vast majority of promising therapeutic agents—including nearly all large-molecule biologics and most small-molecule drugs—from reaching their intended neural targets…

10. Everyone has the right on arrest or detention

    (a) to be informed promptly of the reasons therefor;

    (b) to retain and instruct counsel without delay and to be informed of that right; and

    (c) to have the validity of the detention determined by way of habeas corpus and to be released if the detention is not lawful.

11. Any person charged with an offence has the right

    (a) to be informed without unreasonable delay of the specific offense;

7. Everyone has the right to life, liberty and security of the person and the right not to be deprived thereof except in accordance with the principles of fundamental justice.

8. Everyone has the right to be secure against unreasonable search or seizure.

9. Everyone has the right not to be arbitrarily detained or imprisoned.

2. Everyone has the following fundamental freedoms:

   (a) freedom of conscience and religion;

   (b) freedom of thought, belief, opinion and expression,

   including freedom of the press and other media of communication;

   (c) freedom of peaceful assembly; and

   (d) freedom of association.